miR-1225-3p regulates fibrosis in mesangial cells via SMURF2-mediated ubiquitination of ChREBP in diabetic kidney disease

Background Diabetic kidney disease (DKD), characterized by mesangial fibrosis and renal dysfunction, is a major microvascular complication of diabetes. Studies have shown that miRNAs are closely related to the progression of DKD. Therefore, in this study, we aimed to explore whether miR-1225-3p can...

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Bibliographic Details

Published in:	Renal Failure
Main Authors:	Juntai Zhang, Yan Cai, Yan Qin, Jie Liu, Jie Ding, Mengying Xu, Li Yang, Yuanxin Zheng, Xi Zhang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Diabetic kidney disease renal fibrosis ChREBP ARHGAP5 miR-1225-3p SMURF2
Online Access:	https://www.tandfonline.com/doi/10.1080/0886022X.2025.2484632