The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2

Nonreceptor tyrosine phosphatases (NTPs) play an important role in regulating protein phosphorylation and have been proposed as attractive therapeutic targets for cancer and metabolic diseases. We have previously identified that 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one (HODHBt) enhanced STAT activatio...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	J. Natalie Howard, Thomas D. Zaikos, Callie Levinger, Esteban Rivera, Elyse K. McMahon, Carissa S. Holmberg, Joshua Terao, Marta Sanz, Dennis C. Copertino Jr., Weisheng Wang, Natalia Soriano-Sarabia, R. Brad Jones, Alberto Bosque
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2024-09-01
Subjects:	AIDS/HIV
Online Access:	https://doi.org/10.1172/jci.insight.179680