Integrated bioinformatics and validation reveal TMEM45A in systemic lupus erythematosus regulating atrial fibrosis in atrial fibrillation

Abstract Background Accumulative evidence has shown that systemic lupus erythematosus (SLE) increases the risk of various cardiovascular diseases including atrial fibrillation (AF). The study aimed to screen potential key genes underlying co-pathogenesis between SLE and AF, and to discover therapeut...

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Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Hongjie Xu, Sufan Ding, Xiaoping Ning, Ye Ma, Qi Yu, Yi Shen, Lin Han, Zhiyun Xu
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Systemic lupus erythematosus Atrial fibrillation Bioinformatics TMEM45A Fibrosis
Online Access:	https://doi.org/10.1186/s10020-025-01162-0