RNA-mediated toxicity in C9orf72 ALS and FTD

A GGGGCC hexanucleotide repeat expansion in the first intron of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Compelling evidence suggests that gain of toxicity from the bidirectionally transcribed repeat expanded RNAs plays a central role in...

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Bibliographic Details
Published in:Neurobiology of Disease
Main Authors: Zachary T. McEachin, Janani Parameswaran, Nisha Raj, Gary J. Bassell, Jie Jiang
Format: Article
Language:English
Published: Elsevier 2020-11-01
Subjects:
Amyotrophic lateral sclerosis
Frontotemporal dementia
C9orf72
RNA-mediated toxicity
RNA foci
Dipeptide repeat proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303302

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http://www.sciencedirect.com/science/article/pii/S0969996120303302

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