A-485 alleviates postmenopausal osteoporosis by activating GLUD1 deacetylation through the SENP1-Sirt3 signal pathway

Abstract Objective Postmenopausal osteoporosis (OP) is a bone disease caused by estrogen deficiency. A-485 is a selective inhibitor of p300/CBP histone acetyltransferase (HAT) with potential regulatory effects on bone remodeling. This study aims to investigate the effects of A-485 on postmenopausal...

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出版年:	Journal of Orthopaedic Surgery and Research
主要な著者:	Yinghong Ma, Xiaohua Zou, Qianhong Jian, Jiaxin Dong, Xianbing Huang, Yue Zhai, Li Qian
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-05-01
主題:	A-485 SENP1-Sirt3 signal pathway GLUD1 Osteoporosis
オンライン･アクセス:	https://doi.org/10.1186/s13018-025-05839-4