TMP-M2Align: A Topology-Aware Multiobjective Approach to the Multiple Sequence Alignment of Transmembrane Proteins

Transmembrane proteins (TMPs) constitute approximately 30% of the mammalian proteome and are critical targets in biomedical research due to their involvement in signaling, transport, and drug interactions. However, their unique structural characteristics pose significant challenges for conventional...

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Bibliographic Details

Published in:	Algorithms
Main Authors:	Joel Cedeño-Muñoz, Cristian Zambrano-Vega, Antonio J. Nebro
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	multiple sequence alignment transmembrane proteins multiobjective optimization evolutionary algorithms GPCR
Online Access:	https://www.mdpi.com/1999-4893/18/10/640