DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

Aging is the continuous degradation of biological function and structure with time, and cellular senescence lies at its core. DNA damage response (DDR) can activate Ataxia telangiectasia-mutated serine/threonine kinase (ATM) and Rad3-related serine/threonine kinase (ATR), after which p53 activates p...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Hao Xiong, Fuzhou Hua, Yao Dong, Yue Lin, Jun Ying, Jie Liu, Xifeng Wang, Lieliang Zhang, Jing Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	DNA damage response CGATA4 cellular senescence atherosclerosis heart failure
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.933015/full