Identification of a presymptomatic and early disease signature for amyotrophic lateral sclerosis (ALS): protocol of the premodiALS study

Abstract Introduction The median time to diagnosis of amyotrophic lateral sclerosis (ALS) is approximately 12 months after the onset of first symptoms. This diagnostic delay is primarily due to the nonspecific nature of early symptoms and the clinical challenges in differentiating ALS from its mimic...

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Published in:	Neurological Research and Practice
Main Authors:	Laura Tzeplaeff, Ana Galhoz, Clara Meijs, Lucas Caldi Gomes, Andrej Kovac, Amrei Menzel, Hatice Değirmenci, Abir Alaamel, Hüseyin Can Kaya, Ali Günalp Çelik, Sine Dinçer, Meltem Korucuk, Sibel Berker Karaüzüm, Elif Bayraktar, Vildan Çiftçi, Uğur Bilge, Filiz Koç, Antonia F. Demleitner, Anne Buchberger, Ricarda von Heynitz, Vincent Gmeiner, Christina Knellwolf, Mohammed Mouzouri, Joanne Wuu, A. Nazli Başak, Peter Munch Andersen, Florian Kohlmayer, Nicholas J. Ashton, Wojciech Kuban, Christof Lenz, Mary-Louise Rogers, Norbert Zilka, Philippe Corcia, Yossef Lerner, Markus Weber, Monika Turcanova Koprusakova, Hilmi Uysal, Michael Benatar, Michael P. Menden, Paul Lingor
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Motoneuron disease Pre-symptomatic Multi-omic Biomarkers Early diagnosis Observational study
Online Access:	https://doi.org/10.1186/s42466-025-00417-9