Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse

Crystalline silica (cSiO2) is a widely recognized environmental trigger of autoimmune disease. In the lupus-prone female NZBWF1 mouse, airway exposure to cSiO2 triggers pulmonary ectopic lymphoid neogenesis, systemic autoantibody elevation, and glomerulonephritis. Here we tested the hypothesis that...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Melissa A. Bates, Abby D. Benninghoff, Kristen N. Gilley, Andrij Holian, Jack R. Harkema, James J. Pestka
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-03-01
Subjects:	autoimmunity NanoString lung systemic lupus erythematosus silica transcriptome
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00632/full