Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes infiltrate the nerve first and rapidly give way to Ly6Cnegative inflammation-resolving macrophages. In axotomized DRGs, few...

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發表在:	eLife
Main Authors:	Ashley L Kalinski, Choya Yoon, Lucas D Huffman, Patrick C Duncker, Rafi Kohen, Ryan Passino, Hannah Hafner, Craig Johnson, Riki Kawaguchi, Kevin S Carbajal, Juan Sebastian Jara, Edmund Hollis, Daniel H Geschwind, Benjamin M Segal, Roman J Giger
格式:	Article
語言:	英语
出版:	eLife Sciences Publications Ltd 2020-12-01
主題:	sciatic nerve injury efferocytosis dorsal root ganglia axon regeneration scRNA sequencing conditioning lesion
在線閱讀:	https://elifesciences.org/articles/60223