Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

Abstract Retromer mediates endosomal retrieval of transmembrane proteins in all eukaryotes and was first discovered in yeast in complex with the Vps5 and Vps17 sorting nexins (SNXs). Cryoelectron tomography (cryoET) studies of Retromer–Vps5 revealed a pseudo-helical coat on membrane tubules where di...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer, Brett M. Collins
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Online Access:	https://doi.org/10.1038/s41467-025-58846-8