Free water imaging reveals asynchronous dopaminergic degeneration in substantia nigra and ventral tegmental area in prodromal and early Parkinson's disease

Purpose: The ventral tegmental area (VTA), which is rich in dopaminergic neurons, may play a role in influencing clinical symptoms in Parkinson's Disease (PD). However, the degeneration dynamics of the VTA during the early and prodromal stages of PD remain unclear. This study aims to explore mi...

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Bibliographic Details

Published in:	Brain Research Bulletin
Main Authors:	Kaiyue Ding, Yu Shen, Yan Bai, Wei Wei, Neil Roberts, Ningli Wang, Xinhui Wang, Guofeng Shen, Xianchang Zhang, Chaowei Sun, Xiaosheng Song, Meiyun Wang
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	Parkinson’s disease Free water imaging Ventral tegmental area Substantia nigra pars compacta Idiopathic REM sleep behavior disorder
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923025001212