PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling

Abstract Background Progesterone and adipose Q receptor 5 (PAQR5), a membrane receptor characterized by seven transmembrane domains, has been indirectly implicated in pro-carcinogenic activities, though its specific role in hepatocellular carcinoma (HCC) remains to be defined. Methods This study aim...

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Bibliographic Details

Published in:	Biomarker Research
Main Authors:	Ruida Yang, Huanhuan Wang, Cong Wu, Yu Shi, Hanqi Li, Xinyue Bao, Yuqian Yang, Shaoshan Han, Xue Yang, Jie Tao, Hao Sun, Shaobo Wu, Liankang Sun
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	PAQR5 Hepatocellular carcinoma NF-κB Single cell-RNA seq Spatial transcriptomic
Online Access:	https://doi.org/10.1186/s40364-025-00785-z