FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Abstract Background Selectively targeting leukemia stem cells (LSCs) is a promising approach in treating acute myeloid leukemia (AML), for which identification of such therapeutic targets is critical. Increasing lines of evidence indicate that FBXO22 plays a critical role in solid tumor development...

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Bibliographic Details

Published in:	Journal of Hematology & Oncology
Main Authors:	Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	FBXO22 Leukemia stem cells (LSCs) Acute myeloid leukemia (AML) BTB and CNC homology 1 (BACH1)
Online Access:	https://doi.org/10.1186/s13045-023-01400-0