Low temperature rather than hypoxia drives cholesterol synthesis and oxygen consumption in plateau zokors

Summary: Subterranean burrows of plateau zokors (Eospalax baileyi) on the Qinghai-Tibet Plateau become significantly colder and more hypoxic with increasing altitude. Because cholesterol biosynthesis is highly oxygen-intensive, it is typically inhibited by hypoxia. Here, our findings revealed that w...

Full description

Bibliographic Details

Published in:	iScience
Main Authors:	Qingfei Hu, Linna Wei, Zhifang An, Yaxuan Wang, Tongzuo Zhang, Dengbang Wei
Format:	Article
Language:	English
Published:	Elsevier 2026-07-01
Subjects:	Zoology Animal physiology Evolutionary biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004226017426