Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by early metastasis and resistance to anti-cancer therapy, leading to an overall poor prognosis. Macroautophagy (hereinafter referred to as autophagy) is a conserved cellular homeostasis mechanism that degrades various cargoes (e.g.,...

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Bibliographic Details

Published in:	Discover Oncology
Main Authors:	Federica Michetti, Mara Cirone, Raffaele Strippoli, Gabriella D’Orazi, Marco Cordani
Format:	Article
Language:	English
Published:	Springer 2025-04-01
Subjects:	Autophagy Pancreatic cancer PDAC Cancer treatment Immune response Tumor microenvironment (TME)
Online Access:	https://doi.org/10.1007/s12672-025-02400-x