Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings

Constant technological advancement enabled the production of therapeutic monoclonal antibodies (mAbs) and will continue to contribute to their rapid expansion. Compared to small-molecule drugs, mAbs have favorable characteristics, but also more complex pharmacokinetics (PK), e.g., target-mediated no...

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Bibliographic Details

Published in:	mAbs
Main Authors:	Eva Germovsek, Ming Cheng, Craig Giragossian
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Subjects:	monoclonal antibody allometric scaling allometry interspecies scaling translation extrapolation
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2021.1964935