Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization?

Background: Because statins were found to decrease the oxygen consumption rate (OCR) of a variety of normal cells, our hypothesis was that statins may also decrease the OCR of cancer cells, alleviate tumor hypoxia and radiosensitize tumors. Methods: OCR was assessed using the Seahorse XF96 technolog...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Donatienne d’Hose, Lionel Mignion, Loïc Hamelin, Pierre Sonveaux, Bénédicte F. Jordan, Bernard Gallez
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Subjects:	statins tumor hypoxia oxygen EPR irradiation oxygen consumption
Online Access:	https://www.mdpi.com/2218-273X/12/10/1418