Multi-omics analysis to uncover the molecular basis of tumor budding in head and neck squamous cell carcinoma

Abstract Tumor budding (TB) is a prognostic biomarker in HPV-negative and HPV-positive head and neck squamous cell carcinoma (HNSCC). Analyzing TCGA and CPTAC mutation, RNA, and RPPA data and performing proteomics and IHC in two independent in-house cohorts, we uncovered molecular correlates of TB i...

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Bibliographic Details

Published in:	npj Precision Oncology
Main Authors:	Iordanis Ourailidis, Fabian Stögbauer, Yuxiang Zhou, Susanne Beck, Eva Romanovsky, Stephan Eckert, Barbara Wollenberg, Markus Wirth, Katja Steiger, Bernhard Kuster, Olivier Gires, Albrecht Stenzinger, Peter Schirmacher, Wilko Weichert, Peer-Hendrik Kuhn, Melanie Boxberg, Jan Budczies
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Online Access:	https://doi.org/10.1038/s41698-025-00856-2