Development and validation of next-generation sequencing-based clinical test for triazole resistance prediction in Aspergillus fumigatus

ABSTRACT The rising rates of triazole drug resistance in Aspergillus fumigatus have placed greater reliance on antifungal susceptibility testing (AFST) to guide therapeutic management, particularly in medically complicated patients. Current methods, however, utilize conventional phenotypic assays th...

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Bibliographic Details

Published in:	Journal of Clinical Microbiology
Main Authors:	J. R. Caldera, Ashley Dayo, Nathan Wiederhold, Shangxin Yang
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-08-01
Subjects:	Aspergillus fumigatus azole resistance whole-genome sequencing genotyping antifungal resistance next-generation sequencing
Online Access:	https://journals.asm.org/doi/10.1128/jcm.00291-25