Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and DNA damage response (DDR) pathways. Aberrations in DNA repair and the DDR are observed in many cancer subtype...

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出版年:	Frontiers in Oncology
主要な著者:	Jeremy M. Kelm, Amirreza Samarbakhsh, Athira Pillai, Pamela S. VanderVere-Carozza, Hariprasad Aruri, Deepti S. Pandey, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-04-01
主題:	DNA repair and DNA damage response (DDR) DNA double-strand break (DSB) repair non-PIKKs inhibitors non-homologous end joining (NHEJ) homology directed repair (HDR) single-strand annealing (SSA)
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fonc.2022.850883/full