CYP3A5 influences oral tacrolimus pharmacokinetics and timing of acute kidney injury following allogeneic hematopoietic stem cell transplantation

Introduction: Polymorphisms in genes responsible for the metabolism and transport of tacrolimus have been demonstrated to influence clinical outcomes for patients following allogeneic hematologic stem cell transplant (allo-HSCT). However, the clinical impact of germline polymorphisms specifically fo...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Pharmacology
المؤلفون الرئيسيون: Nathan D. Seligson, Xunjie Zhang, Mark C. Zemanek, Jasmine A. Johnson, Zachary VanGundy, Danxin Wang, Mitch A. Phelps, Julianna Roddy, Craig C. Hofmeister, Junan Li, Ming J. Poi
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2024-01-01
الموضوعات:
tacrolimus
single nucleotide polymorphism
precision medicine
hematologic stem cell transplant
CYP3A4
CYP3A5
الوصول للمادة أونلاين:https://www.frontiersin.org/articles/10.3389/fphar.2023.1334440/full

الانترنت

https://www.frontiersin.org/articles/10.3389/fphar.2023.1334440/full

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