Recent advances in targeting LRRK2 for Parkinson’s disease treatment

Abstract Parkinson’s disease (PD) is a neurodegenerative disease with severe movement problems. Current treatments mainly focus on symptom management by reducing dopaminergic pathways in the brain. Despite these therapies, ongoing disease progression undermines the effectiveness of prevalent approac...

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書誌詳細

出版年:	Journal of Translational Medicine
主要な著者:	Mahsa Karami, Pantea Majma Sanaye, Atousa Ghorbani, Roshanak Amirian, Pouya Goleij, Mehregan Babamohamadi, Zhila Izadi
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-07-01
主題:	Parkinson’s disease LRRK2 Neurodegenerative diseases Autophagy PROTAC Mitochondrial dysfunction
オンライン･アクセス:	https://doi.org/10.1186/s12967-025-06354-0