Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells

Specific and efficient smooth muscle cell–targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreERT2-Tg mice with mice carrying the loxP-flanked gene. However, the transgene, CreERT2, is not controlled by the endogenous Myh11 gene promoter, and the codon-modified iCreERT2 e...

Full description

Bibliographic Details

Published in:	JCI Insight
Main Authors:	Yang Zhao, Guizhen Zhao, Ziyi Chang, Tianqing Zhu, Ying Zhao, Haocheng Lu, Chao Xue, Thomas L. Saunders, Yanhong Guo, Lin Chang, Y. Eugene Chen, Jifeng Zhang
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2023-07-01
Subjects:	Angiogenesis Vascular biology
Online Access:	https://doi.org/10.1172/jci.insight.171661