Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

Abstract Background The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple lines of evidence indicate a significant contribution of the major cyt...

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Bibliographic Details

Published in:	BMC Biology
Main Authors:	Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop, Agnieszka Chacinska
Format:	Article
Language:	English
Published:	BMC 2018-06-01
Subjects:	Ubiquitination Protein import Protein degradation Proteasome Mitochondria Intermembrane space
Online Access:	http://link.springer.com/article/10.1186/s12915-018-0536-1