Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children

Langerhans cell histiocytosis (LCH) is a disease caused by clonal expansion of CD1a+/CD207+ cells and is characterized by organ involvement and dysfunction. Treatment of LCH in children is risk-adapted, and multisystem LCH requires systemic therapy. Although systemic treatments such as chemotherapy...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Guangqiang Meng, Saran Feng, Yan Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	Langerhans cell histiocytosis allogeneic hematopoietic stem cell transplantation myeloablative conditioning reduced intensity conditioning chimerism
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1345855/full