Downregulation of connexin 43-based gap junctions underlies propofol-induced excessive relaxation in hypertensive vascular smooth muscle cells

Abstract Background Postinduction hypotension caused by propofol remains a non-negligible problem for anesthesiologists, and is especially severe in chronic hypertensive patients with long-term vasoconstriction and decreased vascular elasticity. The functional change in gap junctions composed of Cx4...

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Bibliographic Details
Published in:Cell Communication and Signaling
Main Authors: Weiqi Zeng, Zhizhao Deng, Yingxin Gao, Guoliang Sun, Xianlong Li, Dongdong Yuan
Format: Article
Language:English
Published: BMC 2023-06-01
Subjects:
Angiotensin II
Propofol
Gap junction
Connexin 43
Online Access:https://doi.org/10.1186/s12964-023-01176-3

Internet

https://doi.org/10.1186/s12964-023-01176-3

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