Checkpoint Kinase 1 Stimulates Endogenous Cardiomyocyte Renewal and Cardiac Repair by Binding to Pyruvate Kinase Isoform M2 C‐Domain and Activating Cardiac Metabolic Reprogramming in a Porcine Model of Myocardial Ischemia/Reperfusion Injury

Background The regenerative capacity of the adult mammalian hearts is limited. Numerous studies have explored mechanisms of adult cardiomyocyte cell‐cycle withdrawal. This translational study evaluated the effects and underlying mechanism of rhCHK1 (recombinant human checkpoint kinase 1) on the surv...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Tian‐Wen Wei, Tian‐Kai Shan, Hao Wang, Jia‐Wen Chen, Tong‐Tong Yang, Liu‐Hua Zhou, Di Zhao, Jia‐Teng Sun, Si‐Bo Wang, Ling‐Feng Gu, Chong Du, Qi‐Qi Jiang, Rui Sun, Qi‐Ming Wang, Xiang‐Qing Kong, Xiao‐Hu Lu, Hao‐Liang Sun, Yi Xu, Li‐Ping Xie, Ai‐Hua Gu, Feng Chen, Yong Ji, Xue‐Jiang Guo, Lian‐Sheng Wang
Format:	Article
Language:	English
Published:	Wiley 2024-07-01
Subjects:	metabolic reprogramming myocardial ischemia/reperfusion injury myocardial repair recombinant human checkpoint kinase 1
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.124.034805