Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213

Abstract Background Androgen receptor (AR) plays important role in the development, progression, and metastasis of prostate cancer (PCa). Caffeic acid phenethyl ester (CAPE) is the main component of honey bee propolis. We determined if CAPE affects the signaling and stability of AR in PCa cells. Met...

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Bibliographic Details
Published in:Cell Communication and Signaling
Main Authors: Ying-Yu Kuo, Chieh Huo, Ching-Yu Lin, Hui-Ping Lin, Jai-Shin Liu, Wen-Ching Wang, Chuang-Rung Chang, Chih-Pin Chuu
Format: Article
Language:English
Published: BMC 2019-08-01
Subjects:
Caffeic acid phenethyl ester
AR
CDK1
AKT
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s12964-019-0404-9

Internet

http://link.springer.com/article/10.1186/s12964-019-0404-9

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