The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and <i>C. elegans</i> Worms

Chlordecone (CLD) is an organochlorine pesticide (OCP) that is currently banned but still contaminates ecosystems in the French Caribbean. Because OCPs are known to increase the risk of Parkinson’s disease (PD), we tested whether chronic low-level intoxication with CLD could reproduce certain key ch...

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Bibliographic Details

Published in:	Cells
Main Authors:	Valeria Parrales-Macias, Patrick P. Michel, Aurore Tourville, Rita Raisman-Vozari, Stéphane Haïk, Stéphane Hunot, Nicolas Bizat, Annie Lannuzel
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Subjects:	cell culture model chlordecone dopamine neurons neurodegeneration Parkinsonism tauopathy
Online Access:	https://www.mdpi.com/2073-4409/12/9/1336