Targeting intracellular nontuberculous mycobacteria and M. tuberculosis with a bactericidal enzymatic cocktail

ABSTRACTTo address intracellular mycobacterial infections, we developed a cocktail of four enzymes that catalytically attack three layers of the mycobacterial envelope. This cocktail is delivered to macrophages, through a targeted liposome presented here as ENTX_001. Endolytix Cocktail 1 (EC1) lever...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Helen P. Bartlett, Clinton C. Dawson, Cody M. Glickman, David W. Osborn, Christopher R. Evans, Benjamin J. Garcia, Lauren C. Frost, Jason E. Cummings, Nicholas Whittel, Richard A. Slayden, Jason W. Holder
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-05-01
Subjects:	NTM AMR enzybiotic liposome macrophage capsule
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.03534-23