Essential genes analysis reveals small ribosomal subunit protein eS28 may be a prognostic factor and potential vulnerability in osteosarcoma

Background: Osteosarcoma, the most common primary malignant bone tumor, is currently treated with surgery combined with chemotherapy, but the limited availability of targeted drugs contributes to a poor prognosis. Identifying effective therapeutic targets is crucial for improving the prognosis of os...

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Bibliographic Details

Published in:	Journal of Bone Oncology
Main Authors:	Chao Liang, Juan Zhou, Yongjie Wang, Yin Sun, Jin Zhou, Lan Shao, Zhichang Zhang, Wangjun Yan, Zhiyan Liu, Yang Dong
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	Osteosarcoma CRISPR/Cas9 library Ribosome biogenesis RPS28 eS28 MAPK signal pathways
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212137423000507