CYP3A-Mediated Carbon–Carbon Bond Cleavages in Drug Metabolism

Cytochrome P450 enzymes (P450s) play a critical role in drug metabolism, with the CYP3A subfamily being responsible for the biotransformation of over 50% of marked drugs. While CYP3A enzymes are known for their extensive catalytic versatility, one intriguing and less understood function is the abili...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Junhui Zhou, Xuan Qin, Shenzhi Zhou, Kevin R. MacKenzie, Feng Li
Format:	Article
Language:	English
Published:	MDPI AG 2024-09-01
Subjects:	CYP3A carbon–carbon bond cleavage drug metabolism
Online Access:	https://www.mdpi.com/2218-273X/14/9/1125