Feasibility of stereotactic radiotherapy with pembrolizumab in patients with deficient mismatch repair/microsatellite unstable metastatic colorectal cancer

Background: Patients with metastatic colorectal cancer (mCRC) carrying a deficit in the mismatch repair system/microsatellite instability (dMMR/MSI) show great responses to immune checkpoint inhibitors. However, 30% of patients with dMMR/MSI are primarily immunoresistant, and another 30% develop sec...

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Bibliographic Details

Published in:	ESMO Gastrointestinal Oncology
Main Authors:	A. Gandini, V. Martelli, L. Belgioia, S. Puglisi, M. Cremante, V. Murianni, A. Damassi, C. Pirrone, F. Catalano, M. Grassi, L. Trevisan, S. Vagge, V. Andretta, S. Mammoliti, D. Comandini, G. Fornarini, A. Pessino, A. Pastorino, S. Sciallero, A. Puccini, A.F. Sobrero
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	immunotherapy radiotherapy colorectal cancer immunomodulation abscopal effect combined modality therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S294981982400030X