Efficacy of antiresorptive agents bisphosphonates and denosumab in mitigating hypercalcemia and bone loss in primary hyperparathyroidism: A systematic review and meta-analysis

PurposePrimary hyperparathyroidism (PHPT) is characterized by increased bone remodeling and hypercalcemia. Parathyroidectomy (PTX), the current standard of care, is recommended in all symptomatic and some groups of asymptomatic patients. Anti-resorptive therapies (bisphosphonates and denosumab) have...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Swati Rajput, Aditya Dutta, Singh Rajender, Ambrish Mithal, Naibedya Chattopadhyay
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	primary hyperparathyroidism bisphosphonates denosumab bone mineral density bone turnover markers anti-resorptives
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1098841/full