A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging

IntroductionRecent evidence suggests the blood-to-brain influx rate (K1) in TSPO PET imaging as a promising biomarker of blood–brain barrier (BBB) permeability alterations commonly associated with peripheral inflammation and heightened immune activity in the brain. However, standard compartmental mo...

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出版年:	Frontiers in Neuroscience
主要な著者:	Lucia Maccioni, Carranza Mellana Michelle, Ludovica Brusaferri, Erica Silvestri, Alessandra Bertoldo, Julia J. Schubert, Maria A. Nettis, Valeria Mondelli, Oliver Howes, Federico E. Turkheimer, Michel Bottlaender, Benedetta Bodini, Bruno Stankoff, Marco L. Loggia, Mattia Veronese
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2024-07-01
主題:	BBB IDIF kinetic modeling PET TSPO neuroinflammation
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fnins.2024.1395769/full