Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa

Background: The incidence of olfactory impairment increases with age; however, the detailed molecular and cellular mechanisms underlying this increase are yet to be determined.Methods: We examined the influence of aging on olfactory receptor neurons (ORNs), which are maintained by a unique stem cell...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Rumi Ueha, Shigeyuki Shichino, Satoshi Ueha, Kenji Kondo, Shu Kikuta, Hironobu Nishijima, Kouji Matsushima, Tatsuya Yamasoba
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Subjects:	olfactory receptor neurons aging extracellular matrix genes interleukin-6 insulin-like growth factor 1
Online Access:	http://journal.frontiersin.org/article/10.3389/fnagi.2018.00086/full