Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray

The Smyd1 gene encodes a lysine methyltransferase specifically expressed in striated muscle. Because Smyd1-null mouse embryos die from heart malformation prior to formation of skeletal muscle, we developed a Smyd1 conditional-knockout allele to determine the consequence of SMYD1 loss in mammalian sk...

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Bibliographic Details

Published in:	Disease Models & Mechanisms
Main Authors:	M. David Stewart, Suhujey Lopez, Harika Nagandla, Benjamin Soibam, Ashley Benham, Jasmine Nguyen, Nicolas Valenzuela, Harry J. Wu, Alan R. Burns, Tara L. Rasmussen, Haley O. Tucker, Robert J. Schwartz
Format:	Article
Language:	English
Published:	The Company of Biologists 2016-03-01
Subjects:	Genetics Development Muscle Myocyte SMYD1 Methylation Myopathy
Online Access:	http://dmm.biologists.org/content/9/3/347