Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames

Mutations in PKD1 coding sequence and abnormal PKD1 expression levels contribute to the development of autosomal-dominant polycystic kidney disease, the most common genetic disorder. Regulation of PKD1 expression by factors located in the promoter and 3´ UTR have been extensively studied. Less is kn...

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Bibliographic Details

Published in:	RNA Biology
Main Authors:	Lei Chen, Xia Gao, Xiangshen Liu, Ye Zhu, Dong Wang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	PKD1 ADPKD uORF SNP 5´ UTR
Online Access:	https://www.tandfonline.com/doi/10.1080/15476286.2024.2448387