Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy

Astrocytic glutamate transporters are crucial for glutamate homeostasis in the brain, and dysregulation of these transporters can contribute to the development of epilepsy. Glutamate transporter-1 (GLT-1) is responsible for the majority of glutamate uptake in the dorsal forebrain and has been shown...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Allison R. Peterson, Terese A. Garcia, Kyle Cullion, Seema K. Tiwari-Woodruff, Ernest V. Pedapati, Devin K. Binder
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Subjects:	Epilepsy Glutamate transporter-1 GLT-1 AAV Kainic acid Seizure
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996121001923