The Role of CXCL13 in Antibody Responses to HIV-1 Infection and Vaccination

CXCL13 signals through the G protein-coupled chemokine receptor CXCR5 to drive development of secondary lymphoid tissue as well as B cell and Tfh cell trafficking to germinal centers (GC), which leads to the differentiation of B cells to plasma cells and memory B cells. CXCL13 has been proposed as a...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yonas Bekele Feyissa, Francesca Chiodi, Yongjun Sui, Jay A. Berzofsky
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Subjects:	CXCL13 HIV-1 vaccine CXCR5 broadly neutralizing antibodies
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.638872/full