Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation

Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, and this supports an antiinflammatory phenotype. High laminar shear stress also induces flow-aligned cell elongation and front-rear polarity, but whether these are required for the antiinflammatory phenotype is...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Soon-Gook Hong, Julianne W. Ashby, John P. Kennelly, Meigan Wu, Michelle Steel, Eesha Chattopadhyay, Rob Foreman, Peter Tontonoz, Elizabeth J. Tarling, Patric Turowski, Marcus Gallagher-Jones, Julia J. Mack
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-07-01
Subjects:	Cell biology Vascular biology
Online Access:	https://doi.org/10.1172/JCI175057