Gelsolin regulates intestinal stem cell regeneration and Th17 cellular function

Abstract Intestinal stem cells (ISCs) are responsible for intestinal homeostasis and are important for the regeneration of damaged intestine. We established an ionizing radiation (IR)-induced intestinal injury model and observed that Gelsolin KO mice had increased radiosensitivity. The deletion of G...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Jicong Du, Lan Fang, Yuedong Wang, Jianpeng Zhao, Zhenlan Feng, Yike Yu, Duo Fang, Daqian Huang, Xuanlu Zhai, Ying Cheng, Rui Min, Fu Gao, Cong Liu
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	IR induced intestinal injury Intestinal stem cells (ISCs) Gelsolin (Gelsolin) IL-17 signaling pathway T helper cells 17 (Th17 cells)
Online Access:	https://doi.org/10.1186/s12964-024-01902-5