Optimizing Solvent Selection and Processing Conditions to Generate High Bulk-Density, Co-Precipitated Amorphous Dispersions of Posaconazole

Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs), notable for its ability to enable the production of ASDs containing pharmaceuticals with thermal instability and limited solubility. As is true for spray drying and other unit operations to generate amorphous mate...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Derek Frank, Luke Schenck, Athanas Koynov, Yongchao Su, Yongjun Li, Narayan Variankaval
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	co-precipitated amorphous dispersion posaconazole Form III Form γ processing–performance relationship solvent selection
Online Access:	https://www.mdpi.com/1999-4923/13/12/2017