Thiol Isomerases: Enzymatic Mechanisms, Models of Oxidation, and Antagonism by Galloylated Polyphenols

Thiol isomerases are a family of enzymes that participate in oxidative protein folding. They contain highly reactive vicinal thiols in a CXXC motif within their catalytic domains to mediate thiol-disulfide switching as part of their reductase, oxidase, and isomerase activity. In addition, they parti...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Osamede C. Owegie, Quinn P. Kennedy, Pavel Davizon-Castillo, Moua Yang
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	thiol isomerase disulfides protein disulfide isomerase polyphenol thrombosis hemostasis
Online Access:	https://www.mdpi.com/2076-3921/14/10/1193