Positional Cloning of cobblestone, a Mouse Mutant Showing Major Defects in Brain Development, Identifies Ift88 as a Candidate Gene

The ENU-induced cobblestone (cbs) mouse mutant exhibits severe defects in fore- and midbrain development. Via genomic mapping, the causative mutation for the cbs-phenotype has previously been located on chromosome 14 in the proximity of the gene Ift88 (Intraflagellar transport, 88 kDa). The Ift88 pr...

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Bibliographic Details

Published in:	Impulse: The Premier Undergraduate Neuroscience Journal
Main Authors:	Marc A. Willaredt, Valentin Evsyukov, Kerry L. Tucker
Format:	Article
Language:	English
Published:	Appalachian State University Honors College 2010-03-01
Subjects:	cortex heterotopia Ift88 intraflagellar transport primary cilia SNP
Online Access:	http://impulse.appstate.edu/sites/impulse.appstate.edu/files/2010EvsyukovFinal2MAR10.pdf