Increased ROS levels activate AMPK-ULK1-mediated mitophagy to promote pseudorabies virus replication

Abstract Increasing evidence has confirmed that oxidative stress plays a nonnegligible role in the viral pathogenic process. In this study, we investigated the role of reactive oxygen species (ROS) in the replication of pseudorabies virus (PRV). Our data showed that PRV infection initially enhanced...

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Bibliographic Details

Published in:	Veterinary Research
Main Authors:	Yuan Zhao, Xiaoyi Qi, Zhenbang Zhu, Wenqiang Wang, Wei Wen, Xiangdong Li
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Pseudorabies virus reactive oxygen species mitophagy AMPK mitochondria Ca2+ Nrf2
Online Access:	https://doi.org/10.1186/s13567-025-01595-9