Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential

Abstract Mouse embryonic stem cells (mESCs) cycle in and out of a transient 2-cell (2C)-like totipotent state, driven by a complex genetic circuit involves both the coding and repetitive sections of the genome. While a vast array of regulators, including the multi-functional protein Rif1, has been r...

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Bibliographic Details
Published in:Cell Regeneration
Main Authors: Lu Li, Pishun Li, Jiale Chen, Li Li, Yunfan Shen, Yangzixuan Zhu, Jiayi Liu, Lu Lv, Song Mao, Fang Chen, Guang Hu, Kai Yuan
Format: Article
Language:English
Published: SpringerOpen 2022-08-01
Subjects:
2C-like
Totipotency
MERVL
Rif1
PRC1.6
Online Access:https://doi.org/10.1186/s13619-022-00124-9

Internet

https://doi.org/10.1186/s13619-022-00124-9

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