Termination Based on Event Accrual in Per Protocol Versus Intention to Treat in the ROCKET AF Trial

Background In event‐driven clinical trials, study termination is based on accrual of a target number of primary efficacy events. For noninferiority trials in which superiority is conditionally examined, the ideal cohort in which to track event accrual is unclear. We used data from the ROCKET AF (Riv...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Anthony P. Carnicelli, Anne S. Hellkamp, Kenneth W. Mahaffey, Daniel E. Singer, Günter Breithardt, Jonathan L. Halperin, Graeme J. Hankey, Jonathan P. Piccini, Richard C. Becker, Christopher C. Nessel, Scott D. Berkowitz, Keith A. A. Fox, Robert M. Califf, Manesh R. Patel
Format:	Article
Language:	English
Published:	Wiley 2021-10-01
Subjects:	anticoagulation atrial fibrillation clinical trial embolic stroke research methodology warfarin
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.121.022485