Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones

A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones. The strategy involved widening the activation energy of the main reaction and side reaction through intermolecular interactions, thereby increasing the...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Hui Sun, Li-Heng Yang, Meng-Yun Fu, Bin Cui
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	domino reactions chemoselectivity ?-functionalization of carbonyl compounds DFT calculation
Online Access:	https://www.mdpi.com/1420-3049/30/5/1114